Structure of PDB 7zwr Chain A Binding Site BS01

Receptor Information

>7zwr Chain A (length=123) Species: 9606 (Homo sapiens)

SCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGL
FYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVM
ATAMYLQMEHVVDTCRKFIKASE

Ligand information

>7zwr Chain B (length=5) Species: 32630 (synthetic construct)

AWVIP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zwr Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
• Resolution: 1.47 Å
• Binding residue (original residue number in PDB): I9 Q10 F11 T12
• Binding residue (residue number reindexed from 1): I3 Q4 F5 T6

External links

• PDB: RCSB:7zwr, PDBe:7zwr, PDBj:7zwr
• PDBsum: 7zwr
• PubMed: 36329085
• UniProt: P41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)