Structure of PDB 7zvj Chain A Binding Site BS01

Receptor Information
>7zvj Chain A (length=583) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILA
TLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPA
NLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLPW
PALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIF
NAVIKQNPFLVYQLPCFWNVQLSQCVSDLKVIHWNKHVEFFRNLYLTFLE
YDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRT
HLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLS
DAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHIST
PYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSF
PKSKAELLSMLDMGTLFTFTNFAKWRTATTPYRVEWEADFEPYVVVRRDC
PEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKF
NKQYRICLKTLKEEFQQDMSRRYGFAALKYLTA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7zvj Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zvj Structural basis for matriglycan synthesis by the LARGE1 dual glycosyltransferase.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		D565 H705 H708
Binding residue
(residue number reindexed from 1)		D409 H538 H541
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.-.-
2.4.1.-
2.4.2.-
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7zvj, PDBe:7zvj, PDBj:7zvj
PDBsum7zvj
PubMed36512577
UniProtO95461|LARG1_HUMAN Xylosyl- and glucuronyltransferase LARGE1 (Gene Name=LARGE1)

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