Structure of PDB 7zt5 Chain A Binding Site BS01

Receptor Information
>7zt5 Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPW
MAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCE
LLEDGSTTGFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQHE
LLYQKNWLEEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALF
CKAHGFYPPEIYMTWMKNEIVQEIDYGDILPSGDGTYQAWASIELDPQSS
NLYSCHVEHSGVHMVLQV
Ligand information
Ligand ID7ZS
InChIInChI=1S/C8H6O4/c9-4-5-2-1-3-6(7(5)10)8(11)12/h1-4,10H,(H,11,12)
InChIKeyYOEUNKPREOJHBW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC(=O)c1cccc(C=O)c1O
OpenEye OEToolkits 2.0.6c1cc(c(c(c1)C(=O)O)O)C=O
FormulaC8 H6 O4
Name3-methanoyl-2-oxidanyl-benzoic acid
ChEMBL
DrugBank
ZINCZINC000000507925
PDB chain7zt5 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zt5 Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		Y7 R9 S24 K43 W69
Binding residue
(residue number reindexed from 1)		Y8 R10 S25 K44 W70
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7zt5, PDBe:7zt5, PDBj:7zt5
PDBsum7zt5
PubMed37382893
UniProtQ95460|HMR1_HUMAN Major histocompatibility complex class I-related gene protein (Gene Name=MR1)

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