Structure of PDB 7zrt Chain A Binding Site BS01

Receptor Information
>7zrt Chain A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
Ligand information
>7zrt Chain B (length=16) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CSRFVVDCRGRGGPCG
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zrt Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
Resolution1.8 Å
Binding residue
(original residue number in PDB)		R20 H22 R23 Y29 V30 C31 H46 I49 D50 Y150 D192 S193 C194 Q195 G196 S198 G219 G221
Binding residue
(residue number reindexed from 1)		R20 H22 R23 Y29 V30 C31 H46 I49 D50 Y150 D192 S193 C194 Q195 G196 S198 G219 G221
Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7zrt, PDBe:7zrt, PDBj:7zrt
PDBsum7zrt
PubMed
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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