Structure of PDB 7zm7 Chain A Binding Site BS01

Receptor Information
>7zm7 Chain A (length=711) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEVELTIDGKKVSIEAGSALIQACEKAGVVVPRYCYHEKLAIAGNCRMCL
VEVERSPKPVASCAWPVQAGMVVKTNSPLTHKAREGVMEFLLANHPLDCP
ICDQGGECDLQDQSMRYGADRGRFHEIGGKRAVEDKNIGPLIKTSMNRCI
HCTRCVRFMNDIAGAPELGSTGRGNDLQIGTYLEKNLDSELSGNVIDLCP
VGALTSKPYAFRARPWELKRTESIDVLDGLGSNIRVDSRGLEVMRILPRL
NDDVNEEWINDKTRFACDGLKTQRLTMPLVRRDGKFEPATWEQALTEIAH
AYQTLAPKENEFKVIAGQLVEVESLVAMKDLANRLGSENLALDFPGGSQP
LAHGVDIRSNYLFNSKIWGIEEADAILLVGTNPRHEAAVLNARIRKQWLR
SDLEIAAVGQPWESTFDYEHLGTDLAALKNALSGPFGEKLKKAKRPMIIV
GSGVTEHPDAKAFYETVWSFVEKNASNFLTEEWCGYNVLQRAASRAGAFE
VGFVVPSPEVAATKPKFVWLLGADEFDPADVPKDAFIVYQGHHGDRGAEI
ADIVLPGAAYTEKAGTYVNTEGRVQMTRAATGLPGAARTDWKIIRAVSEF
LGVPLPYDDVAQLRDRMAEISPALAAYDVVEPVALRHLSKVQLVDQNKGA
KVTGEPLKKVVENFYFTDVISRSSPTMARCSAAKETGDPRTNFMAPGMEE
DRPMGQIAYGA
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7zm7 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7zm7 Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum.
Resolution2.77 Å
Binding residue
(original residue number in PDB)		R71 C73 Y74 G82 C84 R85 C87 C101
Binding residue
(residue number reindexed from 1)		R33 C35 Y36 G44 C46 R47 C49 C63
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zm7, PDBe:7zm7, PDBj:7zm7
PDBsum7zm7
PubMed36427319
UniProtG0RYA1

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