Structure of PDB 7zl3 Chain A Binding Site BS01

Receptor Information
>7zl3 Chain A (length=388) Species: 9940 (Ovis aries) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCPYWMRVILASNRGTL
MALGISPIVTSGLIMQLLAGATPKDRALFNGAQKLFGMTITIGQSIVYVM
TVCLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKA
FSPTTVNTGRGMEFEGAIIALFHLLALREAFYRQNLPNLMNLIATIFVFA
VVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYV
ISQMLSARPVGGLCHYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKT
WIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCI
GALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQS
Ligand information
>7zl3 Chain C (length=28) Species: 9940 (Ovis aries) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAAAAAGGA
Receptor-Ligand Complex Structure
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PDB7zl3 Signal peptide mimicry primes Sec61 for client-selective inhibition.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		V14 P17 E18 W34
Binding residue
(residue number reindexed from 1)		V4 P7 E8 W24
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005048 signal sequence binding
GO:0008320 protein transmembrane transporter activity
GO:0043022 ribosome binding
Biological Process
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0015031 protein transport
GO:0031204 post-translational protein targeting to membrane, translocation
Cellular Component
GO:0005784 Sec61 translocon complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zl3, PDBe:7zl3, PDBj:7zl3
PDBsum7zl3
PubMed37169961
UniProtA0A6P3YN15

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