Structure of PDB 7zjs Chain A Binding Site BS01

Receptor Information
>7zjs Chain A (length=929) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGV
VTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIG
VLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTAL
VNVALNLSINMDNTQRQYEAERNKANERLELLLQKRKELQENQDEIENMM
NAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWT
MHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYD
VAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKK
LFSGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSL
LLEEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGRKVLTAKEKKTQ
LDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLE
KHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQ
LIDELADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKW
DLFACNYKLLKTGIENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKE
DLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFSHQIMSGG
RDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDEDEASKIEALHKRRNLL
AAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQC
AKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFLKTREA
IAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVY
VYLEKFMTFQMSLRREDVWLPLMSYRNSL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7zjs Structural basis of centromeric cohesion protection.
Resolution3.24 Å
Binding residue
(original residue number in PDB)		Y297 R298 D326 K330 Y331 W334 F367
Binding residue
(residue number reindexed from 1)		Y212 R213 D241 K245 Y246 W249 F282
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0090307 mitotic spindle assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0008278 cohesin complex
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030892 mitotic cohesin complex
GO:0097431 mitotic spindle pole

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zjs, PDBe:7zjs, PDBj:7zjs
PDBsum7zjs
PubMed37081319
UniProtQ8N3U4|STAG2_HUMAN Cohesin subunit SA-2 (Gene Name=STAG2)

[Back to BioLiP]