Structure of PDB 7zes Chain A Binding Site BS01

Receptor Information
>7zes Chain A (length=827) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNS
GGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIF
VKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKR
KPDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYV
PAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVH
FCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVE
DKYVCSLTTEKWVGMMTDVYSKKGLEHKKELQQLLFSVPPGYLRYTPESL
WRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDAL
LIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRA
KVLCLSPVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCE
VLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHC
EAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQN
FRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQY
PREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQG
VQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHY
KYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRT
ADPAILPNVLICLASRAKQHLYIFPWG
Ligand information
Receptor-Ligand Complex Structure
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PDB7zes Mechanistic understanding of human SLFN11.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N633 Q634 R674 E676 A816 S853 R856 A873
Binding residue
(residue number reindexed from 1)		N561 Q562 R602 E604 A744 S781 R784 A801
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0002376 immune system process
GO:0006338 chromatin remodeling
GO:0006974 DNA damage response
GO:0008156 negative regulation of DNA replication
GO:0043111 replication fork arrest
GO:0051607 defense response to virus
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zes, PDBe:7zes, PDBj:7zes
PDBsum7zes
PubMed36115853
UniProtQ7Z7L1|SLN11_HUMAN Schlafen family member 11 (Gene Name=SLFN11)

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