Structure of PDB 7z93 Chain A Binding Site BS01

Receptor Information
>7z93 Chain A (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSM
NGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDIHF
InChIInChI=1S/C6H9N3O2/c1-2-3-4(7)5(10)9-6(11)8-3/h2,7H2,1H3,(H2,8,9,10,11)
InChIKeyNHAGBFNQWVFUGY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCC1=C(N)C(=O)NC(=O)N1
OpenEye OEToolkits 2.0.7CCC1=C(C(=O)NC(=O)N1)N
FormulaC6 H9 N3 O2
Name5-azanyl-6-ethyl-1H-pyrimidine-2,4-dione
ChEMBLCHEMBL5180402
DrugBank
ZINC
PDB chain7z93 Chain A Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z93 Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		S417 Y418 D422 W432 C433 S434 W486 W491 D528
Binding residue
(residue number reindexed from 1)		S18 Y19 D23 W33 C34 S35 W87 W91 D128
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z93, PDBe:7z93, PDBj:7z93
PDBsum7z93
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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