Structure of PDB 7z92 Chain A Binding Site BS01

Receptor Information
>7z92 Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSM
NGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRW
IFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDIGT
InChIInChI=1S/C6H9N3O2/c1-3-4(7)5(10)9(2)6(11)8-3/h7H2,1-2H3,(H,8,11)
InChIKeyDMYXWQPNMMVHBF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC1=C(C(=O)N(C(=O)N1)C)N
CACTVS 3.385CN1C(=O)NC(=C(N)C1=O)C
FormulaC6 H9 N3 O2
Name5-azanyl-3,6-dimethyl-1H-pyrimidine-2,4-dione
ChEMBLCHEMBL5175323
DrugBank
ZINC
PDB chain7z92 Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z92 Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.91 Å
Binding residue
(original residue number in PDB)		S417 Y418 D422 W432 C433 S434 W486 W491
Binding residue
(residue number reindexed from 1)		S18 Y19 D23 W33 C34 S35 W87 W92
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z92, PDBe:7z92, PDBj:7z92
PDBsum7z92
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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