Structure of PDB 7z8x Chain A Binding Site BS01

Receptor Information
>7z8x Chain A (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDIGX
InChIInChI=1S/C5H6N2O3/c1-10-4-2-3(8)6-5(9)7-4/h2H,1H3,(H2,6,7,8,9)
InChIKeySWNDNOHEVRPIDI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		COC1=CC(=O)NC(=O)N1
FormulaC5 H6 N2 O3
Name6-methoxy-1H-pyrimidine-2,4-dione
ChEMBLCHEMBL5172278
DrugBank
ZINCZINC000000332734
PDB chain7z8x Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z8x Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		S417 Y418 D422 W432 C433 W486 W491
Binding residue
(residue number reindexed from 1)		S17 Y18 D22 W32 C33 W86 W91
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z8x, PDBe:7z8x, PDBj:7z8x
PDBsum7z8x
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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