Structure of PDB 7z8w Chain A Binding Site BS01

Receptor Information
>7z8w Chain A (length=143) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVY
LLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVP
NSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKH
Ligand information
Ligand IDIHR
InChIInChI=1S/C9H11N5/c1-5-7-8(14-13-5)9(11-4-10-7)12-6-2-3-6/h4,6H,2-3H2,1H3,(H,13,14)(H,10,11,12)
InChIKeyCTRMXAARLMLINT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7Cc1c2c(c(ncn2)NC3CC3)n[nH]1
CACTVS 3.385Cc1[nH]nc2c(NC3CC3)ncnc12
FormulaC9 H11 N5
Name~{N}-cyclopropyl-3-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChEMBLCHEMBL5208578
DrugBank
ZINC
PDB chain7z8w Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z8w Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 D422 W432 C433 W486 W491
Binding residue
(residue number reindexed from 1)		K10 S11 Y12 D16 W26 C27 W80 W85
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z8w, PDBe:7z8w, PDBj:7z8w
PDBsum7z8w
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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