Structure of PDB 7z8p Chain A Binding Site BS01

Receptor Information
>7z8p Chain A (length=147) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDWKGRFDVRWIF
VKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDIFZ
InChIInChI=1S/C6H6BrN5/c1-8-6-4-3(9-2-10-6)5(7)12-11-4/h2H,1H3,(H,11,12)(H,8,9,10)
InChIKeyAOVWLHFPQGGIAW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CNc1ncnc2c(Br)[nH]nc12
OpenEye OEToolkits 2.0.7CNc1c2c(c([nH]n2)Br)ncn1
FormulaC6 H6 Br N5
Name3-bromanyl-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
ChEMBLCHEMBL5192389
DrugBank
ZINC
PDB chain7z8p Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z8p Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 D422 W432 C433 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K16 S17 Y18 D22 W32 C33 W86 W90 D127
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z8p, PDBe:7z8p, PDBj:7z8p
PDBsum7z8p
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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