Structure of PDB 7z7f Chain A Binding Site BS01

Receptor Information
>7z7f Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSM
NGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRW
IFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDIF3
InChIInChI=1S/C8H12N6/c1-9-6-5-7(14(3)4-11-5)13-8(10-2)12-6/h4H,1-3H3,(H2,9,10,12,13)
InChIKeyYFZMXDSHFHHAQH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CNc1c2c(nc(n1)NC)n(cn2)C
CACTVS 3.385CNc1nc(NC)c2ncn(C)c2n1
FormulaC8 H12 N6
Name~{N}2,~{N}6,9-trimethylpurine-2,6-diamine
ChEMBLCHEMBL5173725
DrugBank
ZINC
PDB chain7z7f Chain A Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z7f Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 S419 D422 W432 C433 W486 S487 W491 D528
Binding residue
(residue number reindexed from 1)		K17 S18 Y19 S20 D23 W33 C34 W87 S88 W92 D129
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z7f, PDBe:7z7f, PDBj:7z7f
PDBsum7z7f
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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