Structure of PDB 7z54 Chain A Binding Site BS01

Receptor Information
>7z54 Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKH
Ligand information
Ligand IDOYT
InChIInChI=1S/C9H11N5/c1-10-8-7-9(12-4-11-8)14(5-13-7)6-2-3-6/h4-6H,2-3H2,1H3,(H,10,11,12)
InChIKeyGSKXLJNKAAXSOE-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CNc1ncnc2n(cnc12)C3CC3
OpenEye OEToolkits 2.0.7CNc1c2c(ncn1)n(cn2)C3CC3
FormulaC9 H11 N5
Name9-cyclopropyl-~{N}-methyl-purin-6-amine
ChEMBLCHEMBL5170722
DrugBank
ZINC
PDB chain7z54 Chain A Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z54 Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.82 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 D422 W432 C433 N462 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K16 S17 Y18 D22 W32 C33 N62 W86 W91 D128
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z54, PDBe:7z54, PDBj:7z54
PDBsum7z54
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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