Structure of PDB 7z4u Chain A Binding Site BS01

Receptor Information
>7z4u Chain A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSM
NGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRW
IFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDFIQ
InChIInChI=1S/C8H10N2O2/c1-10-7(11)4-6(5-2-3-5)9-8(10)12/h4-5H,2-3H2,1H3,(H,9,12)
InChIKeySJCKLNPJUZKFGN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CN1C(=O)C=C(NC1=O)C2CC2
CACTVS 3.385CN1C(=O)NC(=CC1=O)C2CC2
FormulaC8 H10 N2 O2
Name6-cyclopropyl-3-methyl-1H-pyrimidine-2,4-dione
ChEMBLCHEMBL5201513
DrugBank
ZINCZINC000166594261
PDB chain7z4u Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z4u Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		S417 Y418 W432 C433 W486 W491
Binding residue
(residue number reindexed from 1)		S18 Y19 W33 C34 W87 W92
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7z4u, PDBe:7z4u, PDBj:7z4u
PDBsum7z4u
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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