Structure of PDB 7z4s Chain A Binding Site BS01

Receptor Information
>7z4s Chain A (length=306) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDML
NPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPK
YKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGF
NIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTI
TVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDIL
GPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTFQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7z4s In vitro selection of macrocyclic peptide inhibitors containing cyclic gamma 2,4 -amino acids targeting the SARS-CoV-2 main protease.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		S46 M49 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 R188 Q189 Q192
Binding residue
(residue number reindexed from 1)		S46 M49 F140 L141 N142 G143 S144 C145 H163 H164 M165 E166 P168 D187 R188 Q189 Q192
Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7z4s, PDBe:7z4s, PDBj:7z4s
PDBsum7z4s
PubMed37217786
UniProtP0DTC1|R1A_SARS2 Replicase polyprotein 1a

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