Structure of PDB 7z42 Chain A Binding Site BS01

Receptor Information

>7z42 Chain A (length=721) Species: 11520 (Influenza B virus)

SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTALEGQGKEQNLRPQYEVIEGMPRTIAWMVQRSLAQEH
GIETPKYLADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFS
YNQDYSLSNESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGDVEKGID
FKLGQTISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVS
VTPKKLTWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKK
PKTLAKECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEE
MSNELQKTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAA
WVQTEMNLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKA
STVMMKYVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAV
KGQSHLRGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREK
SVYLYCRVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTK
ACFKGDRVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQL
EGFSAESRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAY
WFNEWLGFEKEGSKVLESVDE

Ligand information

>7z42 Chain Y (length=3) Species: 9606 (Homo sapiens)

PTS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
• Resolution: 2.418 Å
• Binding residue (original residue number in PDB): L413 K631
• Binding residue (residue number reindexed from 1): L412 K630

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:7z42, PDBe:7z42, PDBj:7z42
• PDBsum: 7z42
• PubMed: 35605026
• UniProt: Q5V8Z9