Structure of PDB 7z2h Chain A Binding Site BS01

Receptor Information

>7z2h Chain A (length=526) Species: 11678 (Human immunodeficiency virus type 1 BH10)

SPIETVPVKLKPGMDGPKVKQWPLTEALVEICTEMEKEGKISKIGPENPY
NTPVFACKKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDA
YFSVPLDEDFRKYTAFTIPIRYQYNVLPQGWKGSPAIFQSSMTKILEPFK
KQNPDIVIYQYIDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQ
KEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYP
GIKVRQLSKLLRGTLTEVIPLTEEAELELAENREILKEPVHGVYYDPSKD
LIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQK
ITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVK
LWYQLEKEPIVGAETFYVDGAANRELGKAGYVTNKGRQKVVPLTNTTNQK
TELQAIYLALQDSGLEVNIVTNSQYALGIIQAQPDKSESELVNQIIEQLI
KKEKVYLAWVPAHKGIGGNEQVDKLV

Ligand information

>7z2h Chain E (length=36)

atacccccccttcggtgctttgcaccgaaggggggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z2h Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
• Resolution: 3.58 Å
• Binding residue (original residue number in PDB): F61 C63 L74 L92 G93 I94 I184 D185 M230 G231 Q242 Q258 K259 K263 N265 W266 S280 R284 K353 R358 G359 H361 R448 T473 Q475 K476 Y501
• Binding residue (residue number reindexed from 1): F55 C57 L60 L78 G79 I80 I162 D163 M208 G209 Q220 Q236 K237 K241 N243 W244 S258 R262 K329 R334 G335 H337 R424 T447 Q449 K450 Y475

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:7z2h, PDBe:7z2h, PDBj:7z2h
• PDBsum: 7z2h
• PubMed: 35858448
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)