Structure of PDB 7z2g Chain A Binding Site BS01

Receptor Information

>7z2g Chain A (length=536) Species: 11678 (Human immunodeficiency virus type 1 BH10)

SPIETVPVKLKPGMDGPKVKQWPKIKALVEICTEMEKEGKISKIGPENPY
NTPVFACKKKRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDV
GDAYFSVPLDEDFRKYTAFTIPGIRYQYNVLPQGWKGSPAIFQSSMTKIL
EPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPD
KKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWAS
QIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVY
YDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQL
TEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVN
TPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVP
LTNTTNQKTELQAIYLALQDSGLEVNIVTNSQYALGIIQAQPDKSESELV
NQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSA

Ligand information

>7z2g Chain E (length=36)

attcccccccttcggtgctttgcaccgaaggggggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z2g Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
• Resolution: 3.65 Å
• Binding residue (original residue number in PDB): W24 P59 V60 F61 L74 R78 N81 E89 Q91 D185 D186 M230 G231 Q258 K259 G262 N265 W266 S280 K353 R358 G359 A360 H361 R448 T473 Y501
• Binding residue (residue number reindexed from 1): W22 P53 V54 F55 L63 R67 N70 E78 Q80 D167 D168 M212 G213 Q240 K241 G244 N247 W248 S262 K335 R340 G341 A342 H343 R430 T455 Y483

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:7z2g, PDBe:7z2g, PDBj:7z2g
• PDBsum: 7z2g
• PubMed: 35858448
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)