Structure of PDB 7z2d Chain A Binding Site BS01

Receptor Information

>7z2d Chain A (length=547) Species: 11678 (Human immunodeficiency virus type 1 BH10)

VPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISK
IGPENPYNTPVFAWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVT
VLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQ
HLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDI
QKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENR
EILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARM
RGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQ
ATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGY
VTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTNSQYALGIIQ
AQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSA

Ligand information

>7z2d Chain E (length=36)

attcccccccttcggtgctttgcaccgaaggggggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z2d Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
• Resolution: 3.38 Å
• Binding residue (original residue number in PDB): Y183 M184 M230 G231 Q242 N255 Q258 K259 K263 S280 G285 R358 G359 A360 R448 T473 Q500 Y501
• Binding residue (residue number reindexed from 1): Y176 M177 M223 G224 Q235 N248 Q251 K252 K256 S273 G278 R351 G352 A353 R441 T466 Q493 Y494

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:7z2d, PDBe:7z2d, PDBj:7z2d
• PDBsum: 7z2d
• PubMed: 35858448
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)