Structure of PDB 7z28 Chain A Binding Site BS01

Receptor Information
>7z28 Chain A (length=859) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTII
LHSHHLQISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLP
YTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCF
DEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMST
YLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYE
DYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSK
LGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPEL
KVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACI
LNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASISGDVKTMMN
TWTLQKGFPLITITVRGRNVHMKQEHYMKGDTGYLWHVPLTFITSKSDMV
HRFLLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGT
HTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGL
NELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERML
RSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQ
STEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKI
KTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMG
TTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFD
KIRVWLQSE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7z28 Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z28 Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		H353 H357 E376
Binding residue
(residue number reindexed from 1)		H309 H313 E332
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0005138 interleukin-6 receptor binding
GO:0005151 interleukin-1, type II receptor binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0008217 regulation of blood pressure
GO:0009617 response to bacterium
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0043171 peptide catabolic process
GO:0045088 regulation of innate immune response
GO:0045444 fat cell differentiation
GO:0045766 positive regulation of angiogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z28, PDBe:7z28, PDBj:7z28
PDBsum7z28
PubMed35833347
UniProtQ9NZ08|ERAP1_HUMAN Endoplasmic reticulum aminopeptidase 1 (Gene Name=ERAP1)

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