Structure of PDB 7z1j Chain A Binding Site BS01

Receptor Information
>7z1j Chain A (length=406) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELKLESVVIVSRHGVRAPTKATQLMQDVTPDAWPTWPVKLGWLTPRGGEL
IAYLGHYQRQRLVADGLLAKKGCPQSGQVAIIADVDERTRKTGEAFAAGL
APDCAITVHTQADTSSPDPLFNPLKTGVCQLDNANVTDAILSRAGGSIAD
FTGHRQTAFRELERVLNFPQSNLCLKREKQDESCSLTQALPSELKVSADN
VSLTGAVSLASMLTEIFLLQQAQGMPEPGWGRITDSHQWNTLLSLHNAQF
YLLQRTPEVARSRATPLLDLIKTALTPHPPQKQAYGVTLPTSVLFIAGHD
TNLANLGGALELNWTLPGQPDNTPPGGELVFERWRRLSDNSQWIQVSLVF
QTLQQMRDKTPLSLNTPPGEVKLTLAGCEERNAQGMCSLAGFTQIVNEAR
IPACSL
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain7z1j Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7z1j Insights to the Structural Basis for the Stereospecificity of the Escherichia coli Phytase, AppA.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		G149 D154 H158
Binding residue
(residue number reindexed from 1)		G145 D150 H154
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.-
3.6.1.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003993 acid phosphatase activity
GO:0008252 nucleotidase activity
GO:0008707 4-phytase activity
GO:0016787 hydrolase activity
GO:0050308 sugar-phosphatase activity
GO:0052745 inositol phosphate phosphatase activity
Biological Process
GO:0016036 cellular response to phosphate starvation
GO:0071454 cellular response to anoxia
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z1j, PDBe:7z1j, PDBj:7z1j
PDBsum7z1j
PubMed35683026
UniProtP07102|PPA_ECOLI Phytase AppA (Gene Name=appA)

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