Structure of PDB 7z03 Chain A Binding Site BS01

Receptor Information

>7z03 Chain A (length=381) Species: 562 (Escherichia coli)

MRILHTSDWHLGQNFYSKSREAEHQAFLDWLLETAQTHQVDAIIVAGDVF
DTGSPPSYARTLYNRFVVNLQQTGCHLVVLAGNQDSVATLNESRDIMAFL
NTTVVASAGHAPQILPRRDGTPGAVLCPIPFLRPRDIITSQAGLNGIEKQ
QHLLAAITDYYQQHYADACKLRGDQPLPIIATGHLTTVGLDAFPAQNFPP
ADYIALGHIHRAQIIGGMEHVRYCGSPIPLSFDECGKSKYVHLVTFSNGK
LESVENLNVPVTQPMAVLKGDLASITAQLEQWRDVSQEPPVWLDIEITTD
EYLHDIQRKIQALTESLPVEVLLVRRSREQRERVLASQQRETLSELSVEE
VFNRRLALEELDESQQQRLQHLFTTTLHTLA

Ligand information

>7z03 Chain E (length=39)

gggccagactggaggtggcaacgccaatcagcaacgact

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z03 Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): N14 F15 Y16 R339
• Binding residue (residue number reindexed from 1): N14 F15 Y16 R325

Gene Ontology

Molecular Function

• GO:0000014 single-stranded DNA endodeoxyribonuclease activity
• GO:0003677 DNA binding
• GO:0004519 endonuclease activity
• GO:0004527 exonuclease activity
• GO:0004529 DNA exonuclease activity
• GO:0005515 protein binding
• GO:0008408 3'-5' exonuclease activity
• GO:0016787 hydrolase activity
• GO:1990238 double-stranded DNA endonuclease activity

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006260 DNA replication
• GO:0006274 DNA replication termination
• GO:0006281 DNA repair
• GO:0006310 DNA recombination

Cellular Component

• GO:1990391 DNA repair complex

External links

• PDB: RCSB:7z03, PDBe:7z03, PDBj:7z03
• PDBsum: 7z03
• PubMed: 35987200
• UniProt: P0AG76|SBCD_ECOLI Nuclease SbcCD subunit D (Gene Name=sbcD)