Structure of PDB 7yzx Chain A Binding Site BS01

Receptor Information

>7yzx Chain A (length=930) Species: 1314 (Streptococcus pyogenes)

TPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLT
DKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEH
GTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYA
QAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSA
GNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATV
KTDDHQAKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIER
GDIDFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDG
LLLKDNSKKTITFNATPKVLPTASDTKLSRFSSWGLTADGNIKPDIAAPG
QDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLD
LAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNT
SSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPK
ALYETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFK
QDPKKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQ
LDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIESSEITETIFAG
TFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLV
AEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGK
VVVNGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRR
LTLASKPKTSQPIYRERIAYTYMDEDPTTEYISPNEDGTFTLPEEAETGT
VPLKMSDFTYVVEDMAGNITYTPVTKLLEG

Ligand information

>7yzx Chain B (length=5) Species: 1314 (Streptococcus pyogenes)

LAPQA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7yzx X-ray diffraction data for the C5a-peptidase mutant with modified activity and specificity.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): K302 R393 D397 F398 I425
• Binding residue (residue number reindexed from 1): K209 R300 D304 F305 I332

Enzymatic activity

• Enzyme Commision number: 3.4.21.110: C5a peptidase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005618 cell wall
• GO:0016020 membrane

External links

• PDB: RCSB:7yzx, PDBe:7yzx, PDBj:7yzx
• PDBsum: 7yzx
• PubMed: 36478677
• UniProt: P15926|C5AP_STRPY C5a peptidase (Gene Name=scpA)