Structure of PDB 7yz9 Chain A Binding Site BS01

Receptor Information
>7yz9 Chain A (length=179) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHG
LEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPV
PLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDE
VYERLKDDFVLRERGVMRTWYLIGRKVAA
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7yz9 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yz9 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		D60 I61 D104
Binding residue
(residue number reindexed from 1)		D15 I16 D59
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7yz9, PDBe:7yz9, PDBj:7yz9
PDBsum7yz9
PubMed35980026
UniProtP9WQ35|CYA1_MYCTU Adenylate cyclase (Gene Name=cya)

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