Structure of PDB 7yxn Chain A Binding Site BS01

Receptor Information
>7yxn Chain A (length=243) Species: 32644 (unidentified) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEFPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVK
WAKALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPD
LVINEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVP
KDGLKSQAVFDEIRMTYIKELGKAIVKRNWQRFYQLTKLLDSMHEMVGGL
LQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7yxn The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
Resolution2.46 Å
Binding residue
(original residue number in PDB)		V575 K579 L589 D590 M593 E755 N759
Binding residue
(residue number reindexed from 1)		V49 K53 L63 D64 M67 E223 N227
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7yxn, PDBe:7yxn, PDBj:7yxn
PDBsum7yxn
PubMed36464162
UniProtA0A1X8XLE9

[Back to BioLiP]