Structure of PDB 7yxc Chain A Binding Site BS01

Receptor Information
>7yxc Chain A (length=245) Species: 32644 (unidentified) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKRESQNWQRFYQLTKLLDSMHEMVGG
LLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7yxc The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		V575 K579 L589 M593 Q597 E755
Binding residue
(residue number reindexed from 1)		V47 K51 L61 M65 Q69 E224
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxc, PDBe:7yxc, PDBj:7yxc
PDBsum7yxc
PubMed36464162
UniProtA0A1X8XLE9

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