Structure of PDB 7yxb Chain A Binding Site BS01

Receptor Information

>7yxb Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGR
FASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELR
EPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHY
LPFLPSTEDVYDCRVEHWGLDEPLLKHWEFD

Ligand information

>7yxb Chain G (length=15) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

VSKMRMATPLLMQAG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yxb MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Resolution	2.095 Å
Binding residue (original residue number in PDB)	Q9 F24 A52 S53 F54 G58 N62 N69 I72 M73 R76
Binding residue (residue number reindexed from 1)	Q9 F24 A52 S53 F54 G58 N62 N69 I72 M73 R76

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:7yxb, PDBe:7yxb, PDBj:7yxb
PDBsum	7yxb
PubMed	37142807
UniProt	P01903\|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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