Structure of PDB 7ywb Chain A Binding Site BS01

Receptor Information
>7ywb Chain A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRS
MNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVR
WIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDN6M
InChIInChI=1S/C6H7N5/c1-7-5-4-6(10-2-8-4)11-3-9-5/h2-3H,1H3,(H2,7,8,9,10,11)
InChIKeyCKOMXBHMKXXTNW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.352CNc1ncnc2[nH]cnc12
ACDLabs 10.04n2c1c(ncn1)c(nc2)NC
OpenEye OEToolkits 1.6.1CNc1c2c([nH]cn2)ncn1
FormulaC6 H7 N5
NameN-METHYL-9H-PURIN-6-AMINE;
N6-METHYL ADENINE
ChEMBLCHEMBL1738843
DrugBank
ZINCZINC000000391197
PDB chain7ywb Chain A Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ywb Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.92 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 D422 W432 C433 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K18 S19 Y20 D24 W34 C35 W88 W93 D130
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7ywb, PDBe:7ywb, PDBj:7ywb
PDBsum7ywb
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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