Structure of PDB 7yvv Chain A Binding Site BS01

Receptor Information

>7yvv Chain A (length=335) Species: 2742131 (Amycolatopsis sp. Hca4)

SALDGLELDYVRFYVGSLDTARDWLVRGYGLGERPWATVRSTEIGANDIR
FVFSEPLVDDHPGTAYVDRHGDGVSDIALRVTDAKAAFEEAVARGARPVA
GPSRAGHVVTASIMGFGDTLHTFVEYPDGPPAPIAVNAEEPGALLEIDHF
AVCVEHGHLDATVDFYRDVLGFELIFAETIAVGSQAMTTKVVQSKSGSVT
FTLIEPDTSKDPGHIDDFLKDHGGAGVQHIAFTSNGIIEAVDVLRDRGVE
FMGTPASYYADLLQRVVPEQYSVPELRTQQVLVDEDHDGQLYQIFARSVH
PRNTIFLELIERLGARGFGSGNITALYQAAERQRD

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 7yvv Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7yvv Characterization of AcmP1 as the native R-4-hydroxymandelate synthase from biosynthetic pathway of Amycolamycins
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): H162 H242 E321
• Binding residue (residue number reindexed from 1): H149 H229 E308
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.

Gene Ontology

Molecular Function

• GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
• GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006572 tyrosine catabolic process
• GO:0009072 aromatic amino acid metabolic process

External links

• PDB: RCSB:7yvv, PDBe:7yvv, PDBj:7yvv
• PDBsum: 7yvv
• UniProt: A0A7H8HIR4