Structure of PDB 7ytw Chain A Binding Site BS01

Receptor Information
>7ytw Chain A (length=507) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMV
SQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKSILALERWKC
PSEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGAL
LSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLR
NLTIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIM
AISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAG
APPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSR
RVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNL
QFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLL
TTEMFVGGCLAFILDNTVPGSPEERGLIQWSYDFPFGMGMVKRTTFFRYI
PICPVFR
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7ytw Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ytw Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E341 D345 S388 S389 S390
Binding residue
(residue number reindexed from 1)		E287 D291 S334 S335 S336
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008520 L-ascorbate:sodium symporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015229 L-ascorbic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0007420 brain development
GO:0009636 response to toxic substance
GO:0015747 urate transport
GO:0015882 L-ascorbic acid transmembrane transport
GO:0030324 lung development
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0043229 intracellular organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ytw, PDBe:7ytw, PDBj:7ytw
PDBsum7ytw
PubMed36914666
UniProtQ9Z2J0|S23A1_MOUSE Solute carrier family 23 member 1 (Gene Name=Slc23a1)

[Back to BioLiP]