Structure of PDB 7ys6 Chain A Binding Site BS01

Receptor Information
>7ys6 Chain A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVM
PPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILS
PLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTLKAS
LTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNP
IIYPLFMRDFKRALGRFLP
Ligand information
Ligand IDSRO
InChIInChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChIKeyQZAYGJVTTNCVMB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc2c(cc1O)c(c[nH]2)CCN
ACDLabs 10.04Oc1cc2c(cc1)ncc2CCN
CACTVS 3.341NCCc1c[nH]c2ccc(O)cc12
FormulaC10 H12 N2 O
NameSEROTONIN;
3-(2-AMINOETHYL)-1H-INDOL-5-OL
ChEMBLCHEMBL39
DrugBankDB08839
ZINCZINC000000057058
PDB chain7ys6 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ys6 Structural insights into constitutive activity of 5-HT 6 receptor.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D106 C110 N288
Binding residue
(residue number reindexed from 1)		D76 C80 N221
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ys6, PDBe:7ys6, PDBj:7ys6
PDBsum7ys6
PubMed36989299
UniProtP50406|5HT6R_HUMAN 5-hydroxytryptamine receptor 6 (Gene Name=HTR6)

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