Structure of PDB 7yp6 Chain A Binding Site BS01

Receptor Information
>7yp6 Chain A (length=414) Species: 911111 (Streptomyces sp. SCSIO 01934) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMRILFATVSEKSHLFTMVPLAWSLAAAGHEVHVASNPALTASIKSTGL
TAVPVGKDHNLHEMDSLENPLSDWSTPELDRHSWEQVLMKFKVSVMFAYQ
TYNDCMVHELVDYARHWQPDLVIWDPVTYAGPVAARVVGAAHARLLWCID
IYAKMREVFLARLAEQPEERREDPMADWLGGILGRYGHTFDEEVVVGQWT
IDQIPTSLQLPLSLRRVPVRYLPHNGPSEIPDWLREAPGRPRVVLTSGVS
ARAALGGTFMPVADMINTLGSMDIDVVAALPPEEVEALEKVPANTRIVDF
VPLHALLPGASVLIHHGGFGSWGTALVNGVPQFIPTIRYADWWNKGTSLH
EAGAGLVVHASELTAEVLRESVERLVEDASYREAAERLREENQRTPTPHD
VVPVIEELTAEHGR
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain7yp6 Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yp6 Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		N228 V252 A282 F303 V304 L306 H319 G323 S324
Binding residue
(residue number reindexed from 1)		N225 V249 A279 F300 V301 L303 H316 G320 S321
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008194 UDP-glycosyltransferase activity
GO:0016740 transferase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7yp6, PDBe:7yp6, PDBj:7yp6
PDBsum7yp6
PubMed36189743
UniProtE5L4T5

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