Structure of PDB 7yoi Chain A Binding Site BS01

Receptor Information

>7yoi Chain A (length=303) Species: 71421 (Haemophilus influenzae Rd KW20)

MAIYADNSYSIGNTPLVRLKHFGHNGNVVVKIEGRNPSYSVKCRIGANMV
WQAEKDGTLTKGKEIVDATSGNTGIALAYVAAARGYKLTLTMPETMSLER
KRLLCGLGVNLVLTEGAKGMKGAIAKAEEIVASDPSRYVMLKQFENPANP
QIHRETTGPEIWKDTDGKVDVVVAGVGTGGSITGISRAIKLDFGKQITSV
AVEPVESPVISQTLAGEEVKPGPHKIQGIGAGFIPKNLDLSIIDRVETVD
SDTALATARRLMAEEGILAGISSGAAVAAADRLAKLPEFADKLIVVILPS
ASE

Ligand information

>7yoi Chain B (length=8) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium)

IGDGYEFT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7yoi Crystal structure of I88L single mutant of O-acetylserine sulfhydrylase from Haemophilus influenzae in complex with high-affinity inhibitory peptide from serine acetyltransferase of Salmonella typhimurium at 2.14 A
• Resolution: 2.14 Å
• Binding residue (original residue number in PDB): S70 G71 M120 Q143 F144 G177 T178 P223 H224 K225 Q227 G228 A231
• Binding residue (residue number reindexed from 1): S70 G71 M120 Q143 F144 G177 T178 P223 H224 K225 Q227 G228 A231

Enzymatic activity

• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0080146 L-cysteine desulfhydrase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7yoi, PDBe:7yoi, PDBj:7yoi
• PDBsum: 7yoi
• UniProt: P45040|CYSK_HAEIN Cysteine synthase (Gene Name=cysK)