Structure of PDB 7ynj Chain A Binding Site BS01

Receptor Information
>7ynj Chain A (length=564) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ILVIAAYFLLVIGVGLWSMCRRSMVWWPVGASLFASNIGSGHFVGLAGTG
AASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRI
RLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIY
TVTGGLYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTV
SEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWC
SDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDE
VACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMS
SLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLP
VVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGG
LLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTL
TVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDEDISEDPSWARVVNLNAL
LMMAVAVFLWGFYA
Ligand information
>7ynj Chain B (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QPWMQGLIAVAVFLVLVAIAFAVNHFWC
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ynj Structures of human SGLT with substrate bound
Resolution3.33 Å
Binding residue
(original residue number in PDB)		L658 M661 V665 F666 G669 F670 A672
Binding residue
(residue number reindexed from 1)		L550 M553 V557 F558 G561 F562 A564
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005362 low-affinity D-glucose:sodium symporter activity
GO:0005412 D-glucose:sodium symporter activity
GO:0005515 protein binding
GO:0015151 alpha-glucoside transmembrane transporter activity
GO:0015293 symporter activity
GO:0015370 solute:sodium symporter activity
GO:0022857 transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0000017 alpha-glucoside transport
GO:0005975 carbohydrate metabolic process
GO:0006814 sodium ion transport
GO:0008645 hexose transmembrane transport
GO:0035623 renal D-glucose absorption
GO:0055085 transmembrane transport
GO:0098708 D-glucose import across plasma membrane
GO:0098719 sodium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ynj, PDBe:7ynj, PDBj:7ynj
PDBsum7ynj
PubMed37217492
UniProtP31639|SC5A2_HUMAN Sodium/glucose cotransporter 2 (Gene Name=SLC5A2)

[Back to BioLiP]