Structure of PDB 7ymh Chain A Binding Site BS01

Receptor Information

>7ymh Chain A (length=270) Species: 9606,10665

KAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLL
LTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR
YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDET
ICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRELKFSREKKAA
KTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI
NPIIYPCSSQEFKKAFQNVL

Ligand information

• Ligand ID: E5E
• InChI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1/t8-/m0/s1
• InChIKey: SFLSHLFXELFNJZ-QMMMGPOBSA-O
• SMILES:
  OpenEye OEToolkits 2.0.6: c1cc(c(cc1C(C[NH3+])O)O)O
  CACTVS 3.385: [NH3+]C[CH](O)c1ccc(O)c(O)c1
  OpenEye OEToolkits 2.0.6: c1cc(c(cc1[C@H](C[NH3+])O)O)O
  CACTVS 3.385: [NH3+]C[C@H](O)c1ccc(O)c(O)c1
• Formula: C8 H12 N O3
• Name: Noradrenaline
• PDB chain: 7ymh Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ymh Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody.
• Resolution: 3.52 Å
• Binding residue (original residue number in PDB): D106 V107 C110 F288 F312
• Binding residue (residue number reindexed from 1): D82 V83 C86 F217 F241
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number:
  3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0016998 cell wall macromolecule catabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7ymh, PDBe:7ymh, PDBj:7ymh
• PDBsum: 7ymh
• PubMed: 37339967
• UniProt: D9IEF7;
  P35348