Structure of PDB 7yhq Chain A Binding Site BS01

Receptor Information
>7yhq Chain A (length=393) Species: 3702,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNV
SDHLSSSAFMSLASQFPVPFVRSTMDTVDWKAIRAADVKEVAETIKSRGM
NHKLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSV
ECVRLLTLHHLAFPVDTNVGRIAVRLGWVPLQPLPESLQLHLLEMYPMLE
SIQKYLWPRLCKLDQKTLYELHYQMITFGKVFCTKSKPNCNACPMKGECR
HFASAFSQLRTEHRVYELPDEHPLLAQLEKREPDDPCSYLLAIWVRGTIL
IPCRTAMRGSFPLNGTYFQVNEVFADHASSLNPINVPIWELPRRTVYFGT
SVPTIFKGLSTEKIQACFWKGYVCVRGFDRKTRGPKPLIARLH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yhq Molecular basis of the plant ROS1-mediated active DNA demethylation.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S902 M905 H907 K908
Binding residue
(residue number reindexed from 1)		S97 M100 H102 K103
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0019104 DNA N-glycosylase activity
GO:0035514 DNA demethylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yhq, PDBe:7yhq, PDBj:7yhq
PDBsum7yhq
PubMed36624257
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q9SJQ6

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