Structure of PDB 7yh4 Chain A Binding Site BS01

Receptor Information

>7yh4 Chain A (length=400) Species: 9606 (Homo sapiens)

LYFQGSLELLKLRSAECIDEAAERLGALSRAIWSQPELAYEEHHAHRVLT
HFFEREPPAASWAVQPHYQLPTAFRAEWEPPEARPRPLHLGFLCEYDALP
GIGHACGHNLIAEVGAAAALGVRGALEGLPRPPPPVKVVVLGTPAEEDGG
GKIDLIEAGAFTNLDVVFMAHPSQENAAYLPDMAEHDVTVKYYGKASHSA
SYPWEGLNALDAAVLAYNNLSVFRQQMKPTWRVHGIIKNGGVKPNIIPSY
SELIYYFRAPSMKELQVLTKKAEDCFRAAALASGCTVEIKGGAHDYYNVL
PNKSLWKAYMENGRKLGIEFIGSTDFGNVSFVVPGIHPYFHIGSNALNHT
EQYTEAAGSQEAQFYTLRTAKALAMTALDVIFKPELLEGIREDFKLKLQE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7yh4 Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7yh4 Crystal structure of human cytosolic beta-alanyl lysine dipeptidase (PM20D2)
• Resolution: 2.03 Å
• Binding residue (original residue number in PDB): C124 E165 H377
• Binding residue (residue number reindexed from 1): C106 E147 H349
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.13.4: Xaa-Arg dipeptidase.

Gene Ontology

Molecular Function

• GO:0004180 carboxypeptidase activity
• GO:0005515 protein binding
• GO:0016787 hydrolase activity
• GO:0016805 dipeptidase activity
• GO:0042802 identical protein binding
• GO:0071713 para-aminobenzoyl-glutamate hydrolase activity

Biological Process

• GO:0006508 proteolysis
• GO:0046657 folic acid catabolic process
• GO:0051246 regulation of protein metabolic process

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm

External links

• PDB: RCSB:7yh4, PDBe:7yh4, PDBj:7yh4
• PDBsum: 7yh4
• UniProt: Q8IYS1|P20D2_HUMAN Xaa-Arg dipeptidase (Gene Name=PM20D2)