Structure of PDB 7yfx Chain A Binding Site BS01

Receptor Information
>7yfx Chain A (length=746) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKQGSKGTPQSLGLNLVKIQCHNEAVYQYHVTFSPNVECKSMRFGMLKDH
QAVTGNVTAFDGSILYLPVKLQQVLELKSQRKTDSAEISIKIQMTKILEP
CSDLCIPFYNVVFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRLQIWPGYA
ASIRRTDGGLFLLADVSHKVIRNDCVLDVMHAIYQQNKEHFQDECTKLLV
GNIVITRYNNRTYRIDDVDWNKTPKDSFTMSDGKEITFLEYYSKNYGITV
KEEDQPLLIHRGEILLLPELSFMTGIPEKMKKDFRAMKDLAQQINLSPKQ
HHSALECLLQRIAKNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLKN
TSFITSQELNWVKEVTRDPSILTIPMHFWALFYPKRAMDQARELVNMLEK
IAGPIGMRMSPPAWVELKDDRIETYVRTIQSTLGAEGKIQMVVCIIMGPR
DDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGG
ELWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVF
QMPHQEIVDSLKLCLVGSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVAN
YEIPQLQKCFEAFENYQPKMVVFVVQKKISTNLYLAAPQNFVTPTPGTVV
DHTITSCEWVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFKL
CHMYWNWPGTIRVPAPCKYAHKLAFLSGHILHHEPAIQLCENLFFL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yfx Structure basis of mammalian Piwi-piRNA silencing machinery
Resolution3.4 Å
Binding residue
(original residue number in PDB)		F258 K262 T272 R328 R329 R341 Y422 R425 Y427 R428 F442 F452 Y455 Y456 H474 E490 I491 L492 Y681 K685 Q697 V698 N700 T703 R709 V713 K716 Q720 N933 W934 K945 K949
Binding residue
(residue number reindexed from 1)		F44 K48 T58 R114 R115 R127 Y208 R211 Y213 R214 F228 F238 Y241 Y242 H260 E263 I264 L265 Y454 K458 Q470 V471 N473 T476 R482 V486 K489 Q493 N706 W707 K718 K722
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0034584 piRNA binding
GO:0046872 metal ion binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0006417 regulation of translation
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0030718 germ-line stem cell population maintenance
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0034587 piRNA processing
GO:0042754 negative regulation of circadian rhythm
GO:0048477 oogenesis
GO:0048511 rhythmic process
GO:0051321 meiotic cell cycle
GO:0060903 positive regulation of meiosis I
GO:0140965 secondary piRNA processing
GO:0140991 piRNA-mediated gene silencing by mRNA destabilization
GO:0141005 retrotransposon silencing by heterochromatin formation
GO:0141006 piRNA-mediated retrotransposon silencing by heterochromatin formation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:0141196 retrotransposon silencing by piRNA-directed DNA methylation
GO:2000767 positive regulation of cytoplasmic translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010370 perinucleolar chromocenter
GO:0033391 chromatoid body
GO:0043186 P granule
GO:0071546 pi-body
GO:0097433 dense body
GO:1990923 PET complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yfx, PDBe:7yfx, PDBj:7yfx
PDBsum7yfx
PubMed38658622
UniProtQ8TC59|PIWL2_HUMAN Piwi-like protein 2 (Gene Name=PIWIL2)

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