Structure of PDB 7yf2 Chain A Binding Site BS01

Receptor Information
>7yf2 Chain A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMAAGGRKENHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSG
WAAIQAYHSAVSSAFSLAMSRTSINGLLGRGSMFVFSPDQFQRLLKINPD
WKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGI
NEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLP
FHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRL
PYLCEGDMYNDYYVLDDAVFVLKPV
Ligand information
Receptor-Ligand Complex Structure
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PDB7yf2 Molecular basis for METTL9-mediated N1-histidine methylation
Resolution1.691 Å
Binding residue
(original residue number in PDB)		N118 R123 G124 M126 N210 D213 R214 V241 L242 P243 H245 Y247 Q267 N268 W269 Q272 Y295 C297 D300 Y302 Y306 L308
Binding residue
(residue number reindexed from 1)		N75 R80 G81 M83 N167 D170 R171 V198 L199 P200 H202 Y204 Q224 N225 W226 Q229 Y252 C254 D257 Y259 Y263 L265
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0106370 protein-L-histidine N-pros-methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yf2, PDBe:7yf2, PDBj:7yf2
PDBsum7yf2
PubMed37015930
UniProtQ9H1A3|METL9_HUMAN Protein-L-histidine N-pros-methyltransferase (Gene Name=METTL9)

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