Structure of PDB 7yev Chain A Binding Site BS01

Receptor Information
>7yev Chain A (length=1128) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKPMSTRIAEATSAIVSKHPARVGLPPTASSGHGYQCHVCSAVLFSPLDL
DAHVASHGLHGNMTLTSSEIQRHITEFISSWQNHPIVQVSADVENRKTAQ
LLHADTPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPF
PEAAVSRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNTETLSV
RGANPLMFRANVLHMLLEFVLDNLYLNRHTGFSQDHTPFTEGANLRSLPG
PDAEKWYSIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSE
WVDVFETSDALTVSIRGRWMARLARMNINPTEIEWALTECAQGYVTVTSP
YAPSVNRLMPYRISNAERQISQIIRVMNIGNNATVIQPVLQDISVLLQRI
SPLQIDPTIISNTMSTVSESTTQTLSPASSILGKLRPSNSDFSSFRVALA
GWLYNGVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPCAPV
KAFMTLANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQLISP
IDAPILRQWAEIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLLPIDHQ
PANVTTPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSMRGT
LGKLKLIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRVPTM
VGVTRQSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPPDLV
TNVWYADAIYPMYADTEVFSNLQRDVITCEAVQTLVTLVAQISETQYPVD
RYLDWIPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPRMTQ
LAIQYQQYNGRTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIARGDII
IGRVQSTHLWSPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAAPMIRD
ETGMMVPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGAYPY
MLHYYDPRQYANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDISSAPAV
QYIISTEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPTQIQ
LPEVVDLYNVVTRYAYETPPITAVVMGV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7yev Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yev In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C183 C186 H199
Binding residue
(residue number reindexed from 1)		C37 C40 H53
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yev, PDBe:7yev, PDBj:7yev
PDBsum7yev
PubMed36469786
UniProtC9E874

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