Structure of PDB 7yer Chain A Binding Site BS01

Receptor Information
>7yer Chain A (length=1316) Species: 1570291 (Ebola virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPDARLSSPIVLDQCDLVTRACGLYSSYSLNPQLRNCKLPKHIYRLKYDV
TVTKFLSDVPVATLPIDFIVPILLKALSGNGFCPVEPRCQQFLDEIIKYT
MQDALFLKYYLKNVGAQEDCVDDHFQEKILSSIQGNEFLHQMFFWYDLAI
LTRRGRLNRGNSRSTWFVHDDLIDILGYGDYVFWKIPISLLPLNTQGIPH
AAMDWYQTSVFKEAVQGHTHIVSVSTADVLIMCKDLITCRFNTTLISKIA
EVEDPVCSDYPNFKIVSMLYQSGDYLLSILGSDGYKIIKFLEPLCLAKIQ
LCSKYTERKGRFLTQMHLAVNHTLEEITEIRALKPSQAHKIREFHRTLIR
LEMTPQQLCELFSIQKHWGHPVLHSETAIQKVKKHATVLKALRPIVIFET
YCVFKYSIAKHYFDSQGSWYSVTSDRNLTPGLNSYIKRNQFPPLPMIKEL
LWEFYHLDHPPLFSTKIISDLSIFIKDRATAVERTCWDAVFEPNVLGYNP
PHKFSTKRVPEQFLEQENFSIENVLSYAQKLEYLLPQYRNFSFSLKEKEL
NVGRTFGKLPYPTRNVQTLCEALLADGLAKAFPSNMMVVTEREQKESLLH
QASTVRGSSFVTDLEKYNLAFRYEFTAPFIEYCNRCYGVKNVFNWMHYTI
PQCYMHVSDYYNPPHNLTLENRNNPPEGPSSYRGHMGGIEGLQQKLWTSI
SCAQISLVEIKTGFKLRSAVMGDNQCITVLSVFPLETDADEQEQSAEDNA
ARVAASLAKVTSACGIFLKPDETFVHSGFIYFGKKQYLNGVQLPQSLKTA
TRMAPLSDAIFDDLQGTLASIGTAFERSISETRHIFPCRITAAFHTFFSV
RILQYHHLGFNKGFDLGQLTLGKPLDFGTISLALAVPQVLGGLSFLNPEK
CFYRNLGDPVTSGLFQLKTYLRMIEMDDLFLPLIAKNPGNCTAIDFVLNP
SGLNVPGSQDLTSFLRQIVRRTITLSAKNKLINTLFHASADFEDEMVCKW
LLSSTPVMSRFAADIFSRTPSGKRLQILGYLEGTRTLLASKIINNNTETP
VLDRLRKITLQRWSLWFSYLDHCDNILAEALTQITCTVDLAQILREYSWA
HILEGRPLIGATLPCMIEQFKVVWLKPYEQCPQCSNAGKPFVSVAVKKHI
VSAWPNASRISWTIGDGIPCPSAALREAIELASRLTWVTQGSSNSDLLIK
PFLEARVNLSVQEILQMTSFMANRMSNSATRLIVSTNTLGEFSDSNIIFQ
NVINYAVALFDIKFRNTEATDIQYNRAHLHLTKCCTREVPAQYLTYTSTL
DLDLTRYRENELIYDN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7yer Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yer Structure of the Ebola virus polymerase complex.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C1150 H1345 H1347
Binding residue
(residue number reindexed from 1)		C1131 H1278 H1280
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yer, PDBe:7yer, PDBj:7yer
PDBsum7yer
PubMed36171293
UniProtA0A1C4HDB0

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