Structure of PDB 7yeh Chain A Binding Site BS01

Receptor Information
>7yeh Chain A (length=1020) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFQGLMELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFECR
RLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK
PDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKA
LGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVT
LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY
YEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTA
LRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLAS
VLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYT
RAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL
AHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGF
RKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHP
TSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIP
CNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTS
GALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKA
VIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSN
TALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAAT
GEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVP
NSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLAD
VCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELI
AKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERL
YLQMWEHYAAGNKPDHMIKP
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain7yeh Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yeh Cryo-EM structure of human OGT-OGA complex
Resolution3.92 Å
Binding residue
(original residue number in PDB)		Q849 F878 V905 A906 K908 H911 H930 T931 T932
Binding residue
(residue number reindexed from 1)		Q830 F859 V886 A887 K889 H892 H911 T912 T913
Annotation score3
Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008289 lipid binding
GO:0008375 acetylglucosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0031490 chromatin DNA binding
GO:0097363 protein O-acetylglucosaminyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000423 mitophagy
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0006110 regulation of glycolytic process
GO:0006111 regulation of gluconeogenesis
GO:0006325 chromatin organization
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007584 response to nutrient
GO:0016485 protein processing
GO:0030097 hemopoiesis
GO:0030336 negative regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0035020 regulation of Rac protein signal transduction
GO:0045727 positive regulation of translation
GO:0045862 positive regulation of proteolysis
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048511 rhythmic process
GO:0051963 regulation of synapse assembly
GO:0060544 regulation of necroptotic process
GO:0071333 cellular response to glucose stimulus
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0160076 negative regulation of non-canonical inflammasome complex assembly
GO:1902455 negative regulation of stem cell population maintenance
GO:1902459 positive regulation of stem cell population maintenance
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0017122 protein N-acetylglucosaminyltransferase complex
GO:0031966 mitochondrial membrane
GO:0032991 protein-containing complex
GO:0042995 cell projection
GO:0044545 NSL complex
GO:0045202 synapse
GO:0070822 Sin3-type complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yeh, PDBe:7yeh, PDBj:7yeh
PDBsum7yeh
PubMed37907462
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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