Structure of PDB 7y8g Chain A Binding Site BS01
Receptor Information
>7y8g Chain A (length=237) Species:
9606
(Homo sapiens) [
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GAGSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLAD
RELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGK
LLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSI
ILLNSGVYEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
Ligand information
>7y8g Chain C (length=8) Species:
9606
(Homo sapiens) [
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AILHRLLQ
Receptor-Ligand Complex Structure
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PDB
7y8g
Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
Resolution
2.14 Å
Binding residue
(original residue number in PDB)
I358 K362 V376 D538 E542 M543
Binding residue
(residue number reindexed from 1)
I57 K61 V75 D227 E231 M232
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7y8g
,
PDBe:7y8g
,
PDBj:7y8g
PDBsum
7y8g
PubMed
37037140
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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