Structure of PDB 7y8f Chain A Binding Site BS01
Receptor Information
>7y8f Chain A (length=236) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
AGAGSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLA
DRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPG
KLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKS
IILLNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
Ligand information
>7y8f Chain C (length=8) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
AILHRLLQ
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
7y8f
Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
Resolution
2.22 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 Q375 V376 D538 L539 E542 M543
Binding residue
(residue number reindexed from 1)
I58 K62 L72 Q75 V76 D226 L227 E230 M231
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7y8f
,
PDBe:7y8f
,
PDBj:7y8f
PDBsum
7y8f
PubMed
37037140
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
[
Back to BioLiP
]
