Structure of PDB 7y7s Chain A Binding Site BS01

Receptor Information

>7y7s Chain A (length=937) Species: 5141 (Neurospora crassa)

HAPVVAARLRNIWPKFPKWLHEAPLAVAWEVTRLFMHCKVDLEDESLGLK
YDPSWSTARDVTDIWKTLYRLDAFRKPFPEKPPNDVFVTAMTGNFESKGS
AVVLSAVLDYNPDNSPTAPLYLVKLKPLMFEQGCRLTRRFGPDRFFEILI
PSPTSTSPSVPPVVSKQPGAVEEVIQWLTMGQHSLVGRQWRAFFAKDAGY
RKPLREFKPIIKERVHFFAETGITFRPDEPVEQRTEFKVSQMLDWLLQLD
NNTWQPHLKLFSRIQLGLSKTYAIMTLEPHQIRHHKTDLLSPSGTGEVMN
DGVGRMSRSVAKRIRDVLGLGDVPSAVQGRFGSAKGMWVIDVDDTGDEDW
IETYPSQRKWECDFVDKHQRTLEVRSVASELKSAGLNLQLLPVLEDRARD
KVKMRQAIGDRLINDLQRQFSEQKHALNRPVEFRQWVYESYSSRATRVSH
GRVPFLAGLPDSQEETLNFLMNSGFDPKKQKYLQDIAWDLQKRKCDTLKS
KLNIRVGRSAYIYMIADFWGVLEENEVHVGFSSKFRDEEESFTLLSDCDV
LVARSPAHFPSDIQRVRAVFKPELHSLKDVIIFSTKGDVPLAKKLSGGDY
DGDMAWVCWDPEIVDGFVNAEMPLEPDLSRYLKKDKTTFKQLMASHGTGS
AAKEQTTYDMIQKSFHFALQPNFLGMCTNYKERLCYINNSVSNKPAIILS
SLVGNLVDQSKQGIVFNEASWAQLRRELLGGALSLPDPMYKSDSWLGRGE
PTHIIDYLKFSIARPAIDKELEAFHNAMAHFWDPDLASYYTFFKEISDKS
RSSALLFTTLKNRIGEVEKEYGRDSKDPYPVRVNQVYEKWCAITPESKVI
RLLELSFLADREMNTWALLRASTAFKLYYHKSPKFVWQMAGRQLAYIKAQ
MTSRPGEGAPALMTAFMYAGLMPDKKFTKQYVARLEG

Ligand information

>7y7s Chain C (length=10)

tatggtcgga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y7s Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): S490 F520 Y590 Q797 S857 Y919 S963 N1080 L1082 G1083 M1084 T1086 N1087 R1091
• Binding residue (residue number reindexed from 1): S100 F130 Y200 Q389 S449 Y511 S555 N672 L674 G675 M676 T678 N679 R683

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity

External links

• PDB: RCSB:7y7s, PDBe:7y7s, PDBj:7y7s
• PDBsum: 7y7s
• PubMed: 36039765
• UniProt: Q9Y7G6