BioLiP

Receptor Information

>7y7p Chain A (length=934) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HAPVVAARLRNIWPKFPKWLHEAPLAVAWEVTRLFMHCKVDLEDESLLKY
DPSWSTARDVTDIWKTLYRLDAFRGKPFPEKPPNDVFVTAMTGNFESKGS
AVVLSAVLDYNPDNSPTPLYLVKLKPLMFEQGCRLTRRFGPDRFFEILIP
SPTSTSPSVPPVVSKQPGAVEEVIQWLTMGQHSLVGRQWRAFFAKDAGYR
KPLREFQPKPIIKERVHFFAETGITFRPDEPVEQRTEFKVSQMLDWLLQL
DNNTWQPHLKLFSRIQLGLSKTYAIMTLEPHQIRHHKTDLLSPSGTGEVM
NDGVGRMSRSVAKRIRDVLGLGDVPSAVQGRFGSAKGMWVIDVDDTGDED
WIETYPSQRKWECDFVDKHQRTLEVRSVASELKSAGLNLQLLPVLEDRAR
DKVKMRQAIGDRLINDLQRQFSEQKHALNRPVEFRQWVYESYSRATRVSH
GRVPFLAGLPDSQEETLNFLMNSGFDPKKQKYLQDIAWDLQKRKCDTLKS
KLNIRVGRSAYIYMIADFWGVLEENEVHVGFSSKFRDEEESFTLLSDCDV
LVARSPAHFPSDIQRVRAVFKPELHSLKDVIIFSTKGDVPLAKKLSGGDY
DGDMAWVCWDPEIVDGFVNAEMPLEPDLSRYLKKDKTTFKQLMASHGTGS
AAKEQTTYDMIQKSFHFALQPNFLGMCTNYKERLCYINNSVSNKPAIILS
SLVGNLVDQSKQGIVFNEASWAQLRRELLGGALSLPDPMYKSDSWLGRGE
PTHIIDYLKFSIARPAIDKELEAFHNAMAHFWDPDLASYYTFFKEISDKS
RSSALLFTTLKNRIGEVEKEYGRLDPYPVRVNQVYEKWCAITPESKVIRL
LELSFLADREMNTWALLRASTAFKLYYHKSPKFVWQMAGRQLAYIKAQMT
SRPGEGAPALMTAFMYAGLMPDKKFTKQYVARLE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7y7p Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Y590 N795 Q797 S857 H858 K909 Y919 S963 M1012 L1082 G1083 M1084 T1086 N1087 D1145
Binding residue (residue number reindexed from 1)	Y199 N388 Q390 S449 H450 K501 Y511 S555 M604 L674 G675 M676 T678 N679 D737

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.

	Molecular Function
GO:0003968	RNA-dependent RNA polymerase activity

PDB	RCSB:7y7p, PDBe:7y7p, PDBj:7y7p
PDBsum	7y7p
PubMed	36039765
UniProt	Q9Y7G6

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Structure of PDB 7y7p Chain A Binding Site BS01