Structure of PDB 7y6u Chain A Binding Site BS01

Receptor Information
>7y6u Chain A (length=1224) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFRRFFSKFNVQAPAVVVLGGYLPIGENQGVNSTWYCAGQHPTASGVHGI
FVSHIRGGHGFEIGISQEPFDPSGYQLYLHKATNGNTNATARLRICQFPS
IKTLGPTANNDVTIGRNCLFNKAIPAHMSEHSVVGITWDNDRVTVFSDKI
YYFYFKNDWSRVATKCYNSGGCAMQYVYEPTYYMLNVTSAGEDGISYQPC
TANCIGYAANVFATEPNGHIPEGFSFNNWFLLSNDSTLVHGKVVSNQPLL
VNCLLAIPKIYGLGQFFSFNQTIDGVCNGAAVQRAPEALRFNINDTSVIL
AEGSIVLHTALGTNFSFVCSNSSNPHLATFAIPLGATQVPYYCFFKVDTY
NSTVYKFLAVLPPTVREIVITKYGDVYVNGFGYLHLGLLDAVTINFTGHG
TDDDVSGFWTIASTNFVDALIEVQGTAIQRILYCDDPVSQLKCSQVAFDL
DDGFYPFSSRNLLSHEQPISFVTLPSFNAHSFVNITVSASFGGHSGANLI
ASDTTINGFSSFCVDTRQFTISLSYNVTNSYGYVSNSQDSNCPFTLQSVN
DYLSFSKFCVSTSLLASACTIDLFGYPEFGSGVKFTSLYFQFTKGELITG
TPKPLEGVTDVSFMTLDVCTKYTIYGFKGEGIITLTNSSFLAGVYYTSDS
GQLLAFKNVTSGAVYSVTPCSFSEQAAYVDDDIVGVISSLSSSTFNSTRE
LPGFFYHSNDGSNCTEPVLVYSNIGVCKSGSIGYVPSQSGQVKIAPTVTG
NISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRCKQLLTQYTAAC
KTIESALQLSARLESVEVNSMLTISEEALQLATISSFNGDGYNFTNVLGV
SVYDPARGRVVQKRSFIEDLLFNKVVTNGLGTVDEDYKRCSNGRSVADLV
CAQYYSGVMVLPGVVDAEKLHMYSASLIGGMVLGGFTAAAALPFSYAVQA
RLNYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEASSQTSRGLNT
VAHALTKVQEVVNSQGAALTQLTVQLQHNFQAISSSIDDIYSRLDPPSAD
VQVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRY
GFCGGDGEHIFSLVQAAPQGLLFLHTVLVPSDFVDVIAIAGLCVNDEIAL
TLREPGLVLFTHELQNHTATEYFVSSRRMFEPRKPTVSDFVQIESCVVTY
VNLTRDQLPDVIPDYIDVNKTRDE
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain7y6u Chain L Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7y6u In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D1176 N1232
Binding residue
(residue number reindexed from 1)		D1146 N1202
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0033644 host cell membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7y6u, PDBe:7y6u, PDBj:7y6u
PDBsum7y6u
PubMed35986008
UniProtA0A1Y0DD46

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