Structure of PDB 7y0i Chain A Binding Site BS01
Receptor Information
>7y0i Chain A (length=56) Species:
9606
(Homo sapiens) [
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SGGRDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNTDVEHYLCEQCD
PRPVDR
Ligand information
>7y0i Chain B (length=15) Species:
9606
(Homo sapiens) [
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ARTKQTARKSTGGKA
Receptor-Ligand Complex Structure
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PDB
7y0i
Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer.
Resolution
N/A
Binding residue
(original residue number in PDB)
D16 E17 G18 L19 M20 I21 W29 T39 V41
Binding residue
(residue number reindexed from 1)
D16 E17 G18 L19 M20 I21 W29 T39 V41
Enzymatic activity
Enzyme Commision number
2.1.1.359
: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.367
: [histone H3]-lysine(9) N-methyltransferase.
External links
PDB
RCSB:7y0i
,
PDBe:7y0i
,
PDBj:7y0i
PDBsum
7y0i
PubMed
36033518
UniProt
Q9NR48
|ASH1L_HUMAN Histone-lysine N-methyltransferase ASH1L (Gene Name=ASH1L)
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